Density of human bone marrow stromal cells regulates commitment to vascular lineages
نویسندگان
چکیده
منابع مشابه
Density of human bone marrow stromal cells regulates commitment to vascular lineages
Mechanisms underlying the vascular differentiation of human bone marrow stromal cells (HBMSCs) and their contribution to neovascularisation are poorly understood. We report the essential role of cell density-induced signals in directing HBMSCs along endothelial or smooth muscle lineages. Plating HBMSCs at high density rapidly induced Notch signaling, which initiated HBMSC commitment to a vascul...
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2011
ISSN: 1873-5061
DOI: 10.1016/j.scr.2011.02.001